Meanwhile, there must be some explanation why the caustic liquid in the vial is proudly called "brilliant green", why it is not used abroad, and what is the general difference between it and iodine?

But let's start in order.

How was the green formula discovered?

William Henry Perkin

In the middle of the 19th century in London, a young scientist William Perkin made desperate attempts to create a cure for malaria.

The chemist conducted various experiments on coal tar, distilling it, subliming it, and poisoning it with acids.

As a result of one of the attempts, Perkin discovered a lilac-colored, persistent substance that was not removed from clothes during washing, which the inventor dubbed "mauveine" in honor of the mallow flower.

He continued experiments, abandoning attempts to save the world from disease, and he managed to synthesize many other organic compounds - resin, also called aniline, dyes: from yellow rivanol and raspberry fuchsin to blue, purple, black - and, finally, green, which We today also get in drugstores.

The production of these dyes was raised to an industrial level when the inventor opened his own factory, the products of which easily replaced the previously used natural dyes - cochineal, indigo and other expensive compounds that could not give a really lasting effect.

Despite the apparent deviation from the originally planned course, the chemist nevertheless made a contribution to the field of medicine.

At first, aniline dyes were used to improve the visibility of microorganism preparations under a microscope, for which they were tinted - however, doctors discovered that it was these dyes that led to the death of experimental microbes.

Finally, they began to be used as antiseptics during surgical operations, childbirth, various injuries, as well as for cleaning medical premises, tools and hands of medical staff.

This entailed a significant reduction in mortality due to sepsis, for which William Perkin was subsequently awarded the title of knight and, coming from a family of a simple builder, became a respected sir.

Why Brilliant Green?

Excuse me, what is such a “diamond” in an ordinary green?

The ear got used to more modest epithets - and wherever “malachite” green went, it is akin to green in composition.

As always, the “damaged phone” is to blame for everything. To obtain a pharmacy solution, green crystals with a golden sheen are dissolved in alcohol, in Latin called “viridis nitentis”, or “green shiny”. Translating to French, pharmacists had to use the word "brillant" - the actual analogue of "brilliant".

And already when translating from French, without much thought, the substance was dubbed "brilliant green" by Russian-speaking doctors. That's the whole secret.

Why is there no greenery abroad?

Surprisingly, but a fact: abroad we will not find greenery either in pharmacies or in medical institutions.

In fact, it continues to flourish only in the CIS countries, where "spotted" children are considered quite normal.

There are two complementary versions of the answer to the question: how do foreigners live without such a necessary drug?

Reason one: for Western medicine, not only the effectiveness is important, but also the aesthetic side of the treatment.

Few of the respectable people of Europe and America can afford to walk down the street and go to work, painted with magenta or greenery - why once again draw attention to their health problems?

After all, much earlier than ours, they changed the white plaster to a coffee shade - so that it was not noticeable.

In a word, for the sake of patient comfort, the “combat medical color” in the West is successfully replaced by the colorless liquid of Castellani with a similar effect, Mercurochrome, various antibiotic ointments and a mixture of betadine (iodine compound) with sugar.

Reason two: Western medicine relies on the principle of "evidence", that is, it requires reference to clinical studies of any of the drugs. Zelenka was invented long before the time when this principle was introduced, and since it is absolutely unprofitable from a commercial point of view to conduct very expensive tests for an old drug, it is easier to abandon it altogether and invent a cart and a cart of analogues sweetened with commercials.

Therefore, the mechanism of the molecular effect of brilliant green on the body to this day remains only hypothetical, as well as the assumption of its possible toxicity and even carcinogenicity.

No one is going to prove or disprove this theory.

What to choose - green or iodine?

In the concept of a five-year-old fidget with forever skinned knees, iodine and green are the same: both are not very pleasant because of the alcohol content, although they are necessary.

But how to determine for sure when to take on a brown jar, and when - for a green vial?

Here we must arm ourselves with elementary ideas about the effect produced by both drugs and their differences.

If with iodine, familiar from the periodic table, everything is more or less clear - its source is sea brown algae - then with "brilliant greens" the situation is somewhat different.

The chemical name of the resulting solution is Bis-(p-diethylamino)triphenylanhydrocarbinol oxalate, with the empirical formula C29H33O4N2.

Since chemistry is not easy for everyone, let's put it simply: a fairly simple composition includes water, ethanol, and, of course, “brilliant green”. Zelenka is a fast-acting, highly active antiseptic that is effective in the fight against Staphylococcus aureus, diphtheria bacillus and gram-positive bacteria - but inferior in power to iodine.

In addition, brilliant green does not dry the skin, so it is used in the treatment of delicate and sensitive skin of babies, as well as in the treatment of small surfaces, scratches or cuts.

But the iodine solution is not applied to damaged skin: it must be used to disinfect the skin around wounds, to dry or blood flow to soft tissues(in case of bruises, sprains, bruises). To do this, they usually draw an iodine grid, and inventive natures sometimes do not mind applying a more whimsical drawing, although, however, this does not affect the treatment process in any way.

Interesting Facts about greenery:

It is interesting that in the Soviet criminal environment there is an expression “to smear (someone) forehead with greenery”, which originally meant execution (the death penalty), and later - simply murder (with the help of firearms). This expression arose during the Stalinist repressions, when the prisoner's number was written in green on the hip of the executed or deceased prisoners.

• Therefore, initially there was an expression: “spread green on the leg”, and they began to talk about “forehead” later, although the forehead had nothing to do with writing the number with green.

• For white rats there is lethal dose greenery. It is enough for them to give 0.05 g / kg.

• In many bactericidal patches, brilliant green is used as an impregnation.

• Zelenka is able to suppress the growth of the tendrils of strawberries and strawberries.

• That is why it is used as part of the drug "Zar-2", which is used in this industry.

• Zelenka formula: C27H33N2*HC2O4*H2O.

• It is primarily an artificial dye.

• Doctors often recommend lubricating large wounds not with iodine, but with brilliant green. They do this because it does not leave any scars on the skin, unlike iodine, which greatly dries the skin, and then burns them with prolonged use.

• Therefore, it is recommended for the treatment of scratches and small wounds. But brilliant green is a milder antiseptic, it does not dry the skin and helps to heal wounds.

• Many advertisers use a solution of brilliant green at presentations, assuring potential buyers "even brilliant green can be washed off."

• However, usually at such events, its weakest solution is used, since the pharmacy option is almost impossible to wash off instantly.

• The most effective medicine that helps cure "chickenpox" is the same brilliant green.

• So far, no drug has coped with this skin skin disease like her.

How to remove greenery?

From surfaces such as wood, plastic and metal, it is wiped off with an alcohol solution. Removing it from the fabric is probably the most difficult.

Most effective way one: the fabric should be moistened abundantly, covered with a cleaning agent or powder, turning it into a paste, leaving it for 30 minutes. You need to remove the stubborn stain manually, with frequent rubbing movements.

Almost all of us from childhood know about such a tool as brilliant green. Its composition, however, is not familiar to everyone. From what and how is this tool made?

Zelenka: composition of the drug

Your parents probably smeared your abrasions, insect bites and wounds more than once with the good old remedy. This antiseptic allows you to disinfect the wound and prevents the spread of pathogenic bacteria. Today it is used for coloring wood and paper, in the manufacture of varnishes and in laboratory tests. In the European Union and America, the drug is prohibited, because. the production of brilliant green is one of the dirtiest in the chemical industry. Perhaps soon this remedy will remain only a memory for the inhabitants of Russia. And it will be replaced by more environmentally friendly and effective means. Also, such a medicine cannot be called aesthetic - green arms and legs in children look even more or less, but what if an adult comes to work in this form?

Zelenka: what is it made of?

In fact, this remedy is a dye that was obtained not in the medical, but in the chemical industry from natural indigo in the distant 19th century. The resulting substance was diverse and bright colors and was suitable for painting almost any surface. Later it turned out that the substance can be produced from coal tar. This is how the predecessor of modern brilliant green appeared - rosolic acid. At first, brilliant green, the composition of which we are studying, was used only as a dye, but soon scientists realized that the remedy also had antiseptic properties. The scope of the drug is gram-positive bacteria. The remedy is used for cuts, abrasions, cracks, pyoderma, blepharitis and herpes. Distinctive feature The fact that brilliant green is not absorbed into the blood when applied to whole skin. If the agent enters the wound, it penetrates into the bloodstream only in an extremely small amount. But such a remedy as brilliant green should not be applied to the mucous membranes. The composition will cause a burn or lead to a secondary infection. The solution must not be taken orally, otherwise severe poisoning and hypoxia may occur.

What is greenery made of?

In dry form, it is a powder or lumps of golden-green color. To obtain the agent, benzaldehyde is condensed with diethylaniline. The resulting substance is oxidized with manganese or lead oxide. The resulting carbinolic base is then reacted with oxalic acid. The finished product is a 1-2% solution of tetraethyl-4,4-diaminotriphenylmethane oxalate in 57% ethanol.

The drug is poorly soluble in water (1 to 50) and in ethanol. The agent mixed with isopropyl alcohol has Blue colour, dissolved in ethanol and water - saturated green. As a component, the substance is contained in Novikov's fluid (collodion, tannin, castor oil, brilliant green, 96% ethanol) and corn fluid (collodion, salicylic acid, 96% ethanol, brilliant green). The drug is incompatible with medicines containing alkalis, active iodine and chlorine.

Let's talk about something like this now...

Few home first-aid kits exist without greenery - a familiar and inexpensive antiseptic from childhood, which even newborns get to know, with which a barely tied navel is treated with this solution. As is often the case with everyday things and phenomena, we do not think about its origin and other "secrets". Meanwhile, there must be some explanation why the caustic liquid in the vial is proudly called "brilliant green", why it is not used abroad, and what is the general difference between it and iodine?

But let's start in order.

How was the green formula discovered?

In the middle of the 19th century in London, a young scientist William Perkin made desperate attempts to create a cure for malaria. The chemist conducted various experiments on coal tar, distilling it, subliming it, and poisoning it with acids. As a result of one of the attempts, Perkin discovered a lilac-colored, persistent substance that was not removed from clothes during washing, which the inventor dubbed "mauveine" in honor of the mallow flower. He continued experiments, abandoning attempts to save the world from disease, and he managed to synthesize many other organic compounds - resin, also called aniline, dyes: from yellow rivanol and crimson fuchsin to blue, purple, black - and, finally, green, which We today also get in drugstores. The production of these dyes was raised to an industrial level when the inventor opened his own factory, the products of which easily replaced the previously used natural dyes - cochineal, indigo and other expensive compounds that could not give a really lasting effect.

Despite the apparent deviation from the originally planned course, the chemist nevertheless made a contribution to the field of medicine. At first, aniline dyes were used to improve the visibility of microorganism preparations under a microscope, for which they were tinted - however, doctors discovered that it was these dyes that led to the death of experimental microbes. Finally, they began to be used as antiseptics during surgical operations, childbirth, various injuries, as well as for cleaning medical premises, tools and hands of medical staff. This entailed a significant reduction in mortality due to sepsis, for which William Perkin was subsequently awarded the title of knight and, coming from a family of a simple builder, became a respected sir.

Why Brilliant Green?

Excuse me, what is such a “diamond” in an ordinary green? The ear got used to more modest epithets - and wherever “malachite” green went, it is akin to green in composition. As always, the “damaged phone” is to blame for everything. To obtain a pharmacy solution, green crystals with a golden sheen are dissolved in alcohol, in Latin called “viridis nitentis”, or “green shiny”. When translating into French, pharmacists had to use the word "brillant" - the actual analogue of "brilliant". And already when translating from French, without much thought, the substance was dubbed "brilliant green" by Russian-speaking doctors. That's the whole secret.

Why is there no greenery abroad?

Surprisingly, but a fact: abroad we will not find greenery either in pharmacies or in medical institutions. In fact, it continues to flourish only in the CIS countries, where "spotted" children are considered quite normal. There are two complementary versions of the answer to the question: how do foreigners live without such a necessary drug?

The first reason: for Western medicine, not only the effectiveness is important, but also the aesthetic side of the treatment. Few of the respectable people of Europe and America can afford to walk down the street and go to work, painted with magenta or green - why once again draw attention to their health problems? After all, much earlier than ours, they changed the white plaster to a coffee shade - so that it was not noticeable. In a word, for the sake of patient comfort, the “combat medical color” in the West is successfully replaced by the colorless liquid of Castellani with a similar effect, Mercurochrome, various antibiotic ointments and a mixture of betadine (iodine compound) with sugar.

Reason two: Western medicine relies on the principle of "evidence", that is, it requires reference to clinical studies of any of the drugs. Zelenka was invented long before the time when this principle was introduced, and since it is absolutely unprofitable from a commercial point of view to conduct very expensive tests for an old drug, it is easier to abandon it altogether and invent a cart and a cart of analogues sweetened with commercials. Therefore, the mechanism of the molecular effect of brilliant green on the body to this day remains only hypothetical, as well as the assumption of its possible toxicity and even carcinogenicity. No one is going to prove or disprove this theory.

What to choose - green or iodine?

In the concept of a five-year-old fidget with forever skinned knees, iodine and green are the same: both are not very pleasant because of the alcohol content, although they are necessary. But how do you know for sure when you need to take on a brown jar, and when - a green vial? Here we must arm ourselves with elementary ideas about the effect produced by both drugs and their differences.

If with iodine, familiar from the periodic table, everything is more or less clear - its source is sea brown algae - then with "brilliant greens" the situation is somewhat different. The chemical name of the resulting solution is Bis-(p-diethylamino)triphenylanhydrocarbinol oxalate, with the empirical formula C29H33O4N2. Since chemistry is not easy for everyone, let's put it simply: a fairly simple composition includes water, ethanol, and, of course, “brilliant green”. Zelenka is a fast-acting, highly active antiseptic that is effective in the fight against Staphylococcus aureus (Staphylococcus aureus), diphtheria bacillus (Corynebacterium diphtheriae) and gram-positive bacteria - but inferior in power to iodine. In addition, brilliant green does not dry the skin, so it is used in the treatment of delicate and sensitive skin of babies, as well as in the treatment of small surfaces, scratches or cuts.

But the iodine solution is not applied to damaged skin: it must be used to disinfect the skin around wounds, for drying or blood flow to soft tissues (in case of bruises, sprains, bruises). To do this, they usually draw an iodine grid, and inventive natures sometimes do not mind applying a more whimsical drawing, although, however, this does not affect the treatment process in any way.

Interesting Zelenka Facts:

It is interesting that in the Soviet and Russian criminal environment there is an expression “to smear (someone) forehead with greenery”, which originally meant execution (the death penalty), and later - simply murder (with the help of firearms). This expression arose during the Stalinist repressions, when the prisoner's number was written in green on the hip of the executed or deceased prisoners. Therefore, initially there was an expression: “spread green on the leg”, and they began to talk about “forehead” later, although the forehead had nothing to do with writing the number with green.

Zelenka artificial dye, his chemical formula- C27H33N2*HC2O4*H2O

Zelenka is used in industry for dyeing (cotton, silk, paper, etc.),

Doctors often recommend lubricating large wounds not with iodine, but with brilliant green. They do this because it does not leave any scars on the skin, unlike iodine, which greatly dries the skin, and then burns them with prolonged use. Therefore, it is recommended for the treatment of scratches and small wounds. But brilliant green is a milder antiseptic, it does not dry the skin and helps to heal wounds.

Many advertisers use a solution of brilliant green at presentations, assuring potential buyers that “even brilliant green can be washed off.” However, usually at such events, its weakest solution is used, since the pharmacy option is almost impossible to wash off instantly.

The most effective medicine that helps cure "chickenpox" is the same brilliant green. So far, no drug has coped with this skin skin disease like her.

sources

http://newsland.com/news/detail/id/541222/

http://i-fakt.ru/interesnye-fakty-o-zelenke/

http://tvoelechenie.ru/medicinskie-fakty/zanimatelnye-fakty-o-zelenke.html

Gross formula

Pharmacological group of the substance Brilliant green

Nosological classification (ICD-10)

CAS code

Characteristics of the substance Brilliant green

Antiseptic agent from the group of dyes.

Greenish-golden lumps or golden-green powder. It is difficult to dissolve in water (1:50) and alcohol; solutions have intense green color. Soluble in chloroform.

Pharmacology

It is a highly active and fast-acting antiseptic. Active against gram-positive bacteria. In the aquatic environment, it is detrimental to the culture of Staphylococcus aureus (Staphylococcus aureus) at a concentration of 1:10000000, its phenol coefficient is 40000 (phenol coefficient is the ratio of the concentrations of phenol and the test antiseptic, in which substances have the same antimicrobial effect, the phenol coefficient is one of the common criteria for assessing the activity of an antiseptic). High sensitivity to brilliant green is detected by diphtheria bacillus (Corynebacterium diphtheriae). In the presence of organic substances, antimicrobial activity decreases: when assessing the activity of this dye in a medium containing 10% blood serum, the phenol coefficient is 120 (0.3% of the value in the aquatic environment).

Application of Brilliant Green

Fresh postoperative and post-traumatic scars, meibomitis (barley), blepharitis, pyoderma, abrasions, cuts, integrity violations skin, erysipelas, folliculitis.

Contraindications

Hypersensitivity.

Side effects of Brilliant Green

Skin irritation; in case of contact with the mucous membrane of the eye - burning, lacrimation.

Interaction

Incompatible with disinfectants containing active iodine, chlorine, alkali (including ammonia solution).

Routes of administration

Outwardly.

Interactions with other active substances

Trade names

Once again, choosing brilliant green instead of the usual iodine as an antiseptic for the wound, we thought: what is it all about? What is iodine and where does it come from, we more or less understand (it is in the periodic table and is made from algae), but brilliant green, or rather Brilliant green solution(so it is written on the jar) we do not understand at all. And why is iodine used in some situations, and brilliant green in others?

We “went” to the Internet: by typing “what is brilliant green” in Yandex, we got a mountain of garbage on the first page of the search engine. The first thing that came across "on the topic" - Dictionary Russian language (Ozhegov S., Shvedova N), where they write:

Zelenka
and, well. (colloquial). The medicine is a green disinfectant liquid in alcohol for the treatment of scratches, cuts, skin diseases. Lubricate with greenery.

But this is not an answer to the question: what is Zelenka in essence and what is it made of ??

Dictionary of Efremova: « Zelenka Zh 1. open. An alcohol solution of brilliant green, used to treat scratches, cuts, etc. 2. Green pasture for livestock; agricultural crops for such feed.»

Again, not that. Let's change the request ... so what is written on the jar? Brilliant green alcohol solution 1%- let's eat it.

Well, here comes Encyclopedias of drugs, pharmaceutical factories and medical sites. They write the same thing:

Russian name: brilliant green
Latin name: Brilliant green
Tradename: Brilliant green (Viride nitens)

Chemical Name: Bis-(p-diethylamino)triphenylanhydrocarbinol oxalate
Gross formula: C29H33O4N2

Description: clear, intense green liquid with an alcohol odour.

Composition by components: brilliant green, water, ethanol.

Characteristic: Antiseptic from the group of dyes.
Greenish-golden lumps or golden-green powder. It is difficult to dissolve in water (1:50) and alcohol; solutions are intense green. Soluble in chloroform.

Pharmacology:
Pharmacological action - antiseptic. Is highly active and fast acting antiseptic ohm. Active against gram-positive bacteria. In the aquatic environment, it has a detrimental effect on the culture of Staphylococcus aureus (Staphylococcus aureus) at a concentration of 1: 10,000,000, its phenol coefficient is 40,000 assessment of antiseptic activity). High sensitivity to brilliant green is detected by diphtheria bacillus (Corynebacterium diphtheriae). In the presence of organic substances, antimicrobial activity decreases: when assessing the activity of this dye in a medium containing 10% blood serum, the phenol coefficient is 120 (0.3% of the value in the aquatic environment).

Application:
Fresh postoperative and post-traumatic scars, meibomitis (barley), blepharitis, pyoderma, abrasions, cuts, violations of the integrity of the skin, erysipelas, folliculitis.

Contraindications: Hypersensitivity.

Side effects: Skin irritation; in contact with the mucous membrane of the eye - burning, lacrimation.

Interaction: Incompatible with disinfectants containing active iodine, chlorine, alkali (including ammonia solution).

Dosage and administration: Externally, applied to the damaged surface, capturing the surrounding healthy tissue.

Caveats: do not allow the drug to come into contact with the mucous membrane of the eye.

Release form: in glass vials.

Storage conditions: in a cool place, away from fire, out of the reach of children.

Best before date: use no later than the date indicated on the package.

Conditions for dispensing from pharmacies: dispensed without a doctor's prescription.

We take out for ourselves: antiseptic from the group of dyes.
It’s already interesting, but it remains unclear: where does it come from, what is it made of, and what is paint? We leaf through the pages of the search engine ... everything is the same.

Then we change the request to "brilliant green" and it seems we are starting to get closer to the goal!

By the way, we forgot about Wikipedia. In it we read:

Brilliant green (drug)
Brillia